MDS杞寲鎴愮櫧琛€鐥呯殑鏃墮棿孌?

MDS鏄楂撳鐢熷紓甯哥患鍚堢棁,鑰屾€ユ€ф棭騫肩矑緇嗚優鐧借鐥?鍙堢ОM3鍨嬫€ユ€х櫧琛€鐥?MDS鍙互鍍忓縐嶇被鍨嬪緱鐧借鐥呰漿鍖?涓村簥娌葷枟鍙嶅簲杈冨樊,妤間富涓昏鎯充簡瑙ｄ粈涔?M3鐜頒粖涓昏娌葷枟榪樻槸鐢ㄥ叏鍙嶅紡緇寸敳閰哥瓑鍖栫枟鑽繘琛屾不鐤?鏁堟灉灝氬彲..鐢熸椿鎶ょ悊:絏濇偍韜綋鍋ュ悍

MDS 鏄竴緇勮搗婧愪簬閫犺騫?絏栫粏鑳炵殑鎭舵€у厠闅嗘€х柧鐥?甯歌浜庝腑鑰佸勾鎮ｈ€?鑷劧鐥呯▼鍙寔緇暟鏈堣嚦鏁板勾,棰勫悗杈冨樊,鐗瑰埆鏄珮鍗盡DS 鎮ｈ€?澶ч儴鍒嗘渶緇堣漿鍙樹負鎬ユ€х櫧琛€鐥?AL).涓庡師鍙戞€ф€ユ€ч珦緇嗚優鎬х櫧琛€鐥呬笉鍚?MDS/AML鎮ｈ€呭甯歌鎴栧己鐑堝寲鐤楃殑鑰愬彈鎬у樊,鏃╂湡鐥呮鐜囬珮,瀹屽叏緙撹В鐜囦綆[4].CAG鏂規鐨勭壒鐐瑰湪浜庤繖鍑犵鑽墿鍦ㄧ粏鑳炲姩鍔涘鏂歸潰鐨勫悎鐞嗙粍鍚?浠-CSF 棰勬縺涓庡皬鍓傞噺Ara-C,Acla 鍚堢敤,鍙互浣垮浜嶨0鏈熺殑鐧借鐥呯粏鑳炶繘鍏鏈?鎻愰珮鐧借鐥呯粏鑳炲鍖栫枟鑽墿鐨勬晱鎰熸€?鍚屾椂鍔犻€熷寲鐤楀悗涓€х矑緇嗚優鐨勬仮澶?鍑忓皯鎰熸煋鐨勫彂鐢?Ara-C 鏄粏鑳炲懆鏈熺壒寮傛€ц嵂鐗?涓昏浣滅敤浜嶴鏈?鍦℅-CSF 瀛樺湪涓?Ara-C 鐨勫崐鏉€浼ゆ祿搴︽樉钁楅檷浣?鐧借鐥呯粏鑳炲洜鎸佷箙鏆撮湶浜庝綆鍓傞噺Ara-C 涓嬭€屼紭鍏堣鏉€浼5].Acla 涓鴻捊鐜被鍒跺墏,鏄粏鑳炲懆鏈熼潪鐗瑰紓鎬ц嵂鐗?鍚孉ra-C涓€鏍峰湪浣庢祿搴︽椂鍏鋒湁璿卞鍒嗗寲浣滅敤[6] .絎旇€呯敤CAG鏂規娌葷枟13渚婱DS杞寲鐨勬€ユ€х櫧琛€鐥呮偅鑰?CR鐜囪揪38.4%,鏈夋晥鐜囪揪61.5%,涓庢枃鐚姤閬撳熀鏈竴鑷碵7,8].搴旂敤CAG鏂規娌葷枟MDS/AML,鍖栫枟鐩稿叧姣掑壇鍙嶅簲杈冭交,鐤楁晥杈冧負婊℃剰,涓村簥涓婃湁涓€瀹氱殑鎺ㄥ箍浠峰€?浣嗚綾繪偅鑰呯紦瑙ｆ椂闂村線寰€杈冪煭,鏁呭浜庤韓浣撶姸鍐佃緝濂界殑騫磋交鎮ｈ€呭簲鍙婃椂琛屽ぇ鍓傞噺寮哄寲娌葷枟,鏈夋潯浠惰€呰閫犺騫茬粏鑳炵Щ妞嶆湳,浜夊彇鑾峰緱闀挎湡鏃犵棶鐢熷瓨MDS 鏄竴緇勮搗婧愪簬閫犺騫?絏栫粏鑳炵殑鎭舵€у厠闅嗘€х柧鐥?甯歌浜庝腑鑰佸勾鎮ｈ€?鑷劧鐥呯▼鍙寔緇暟鏈堣嚦鏁板勾,棰勫悗杈冨樊,鐗瑰埆鏄珮鍗盡DS 鎮ｈ€?澶ч儴鍒嗘渶緇堣漿鍙樹負鎬ユ€х櫧琛€鐥?AL).涓庡師鍙戞€ф€ユ€ч珦緇嗚優鎬х櫧琛€鐥呬笉鍚?MDS/AML鎮ｈ€呭甯歌鎴栧己鐑堝寲鐤楃殑鑰愬彈鎬у樊,鏃╂湡鐥呮鐜囬珮,瀹屽叏緙撹В鐜囦綆[4].CAG鏂規鐨勭壒鐐瑰湪浜庤繖鍑犵鑽墿鍦ㄧ粏鑳炲姩鍔涘鏂歸潰鐨勫悎鐞嗙粍鍚?浠-CSF 棰勬縺涓庡皬鍓傞噺Ara-C,Acla 鍚堢敤,鍙互浣垮浜嶨0鏈熺殑鐧借鐥呯粏鑳炶繘鍏鏈?鎻愰珮鐧借鐥呯粏鑳炲鍖栫枟鑽墿鐨勬晱鎰熸€?鍚屾椂鍔犻€熷寲鐤楀悗涓€х矑緇嗚優鐨勬仮澶?鍑忓皯鎰熸煋鐨勫彂鐢?Ara-C 鏄粏鑳炲懆鏈熺壒寮傛€ц嵂鐗?涓昏浣滅敤浜嶴鏈?鍦℅-CSF 瀛樺湪涓?Ara-C 鐨勫崐鏉€浼ゆ祿搴︽樉钁楅檷浣?鐧借鐥呯粏鑳炲洜鎸佷箙鏆撮湶浜庝綆鍓傞噺Ara-C 涓嬭€屼紭鍏堣鏉€浼5].Acla 涓鴻捊鐜被鍒跺墏,鏄粏鑳炲懆鏈熼潪鐗瑰紓鎬ц嵂鐗?鍚孉ra-C涓€鏍峰湪浣庢祿搴︽椂鍏鋒湁璿卞鍒嗗寲浣滅敤[6] .絎旇€呯敤CAG鏂規娌葷枟13渚婱DS杞寲鐨勬€ユ€х櫧琛€鐥呮偅鑰?CR鐜囪揪38.4%,鏈夋晥鐜囪揪61.5%,涓庢枃鐚姤閬撳熀鏈竴鑷碵7,8].搴旂敤CAG鏂規娌葷枟MDS/AML,鍖栫枟鐩稿叧姣掑壇鍙嶅簲杈冭交,鐤楁晥杈冧負婊℃剰,涓村簥涓婃湁涓€瀹氱殑鎺ㄥ箍浠峰€?浣嗚綾繪偅鑰呯紦瑙ｆ椂闂村線寰€杈冪煭,鏁呭浜庤韓浣撶姸鍐佃緝濂界殑騫磋交鎮ｈ€呭簲鍙婃椂琛屽ぇ鍓傞噺寮哄寲娌葷枟,鏈夋潯浠惰€呰閫犺騫茬粏鑳炵Щ妞嶆湳,浜夊彇鑾峰緱闀挎湡鏃犵棶鐢熷瓨