鑽墿娌葷枟鑲虹値
鏍規嵁鐥呭師浣撶綾夥細鍖呮嫭緇嗚弻鎬ц偤鐐?甯歌緇嗚弻鏈夎偤鐐庨摼鐞冭弻,钁¤悇鐞冭弻,鍡滆嫻佹劅鏉嗚弻絳? 鐥呮瘨鎬ц偤鐐?甯歌鐥呮瘨濡傚懠鍚擱亾鍚堣優鐥呮瘨,嫻佹劅鐥呮瘨,鍓祦鎰熺棶姣?鑵虹棶姣掔瓑.鍙﹀榪樻湁鐪熻弻鎬ц偤鐐?鏀師浣撹偤鐐?琛ｅ師浣撹偤鐐庣瓑.鏍規嵁鏀師浣撳井鐢熺墿瀛︾壒寰?鍑¤兘闃葷寰敓鐗╃粏鑳炲鍚堟垚鐨勬姉鐢熺礌濡傞潚闇夌礌絳?瀵規敮鍘熶綋鏃犳晥.鍥犳,娌葷枟鏀師浣撴劅鏌?搴旈€夌敤鑳芥姂鍒惰泲鐧借川鍚堟垚鐨勬姉鐢熺礌,鍖呮嫭澶х幆鍐呰剛灝?鍥涚幆緔犵被,姘湁緔犵被絳?姝ゅ,灝氭湁鏋楀彲闇夌礌,姘灄鍙湁緔?涓囧彜闇夌礌鍙婄：鑳虹被濡係MZxo絳夊彲渚溳€夌敤.澧炲己浣撹川,鎻愰珮鑷韓鐨勫厤鐤姏,鏄闃茶偤鐐庣殑鏈夋晥閫斿緞.
鍖誨涓婂鑲虹値榪涜浜嗗垎綾夥細銆€銆€鍒嗙被鏂規硶鐨勪緷鎹槸鐥呭師浣撶綾?鐥呯▼鍜岀棶鐞嗗艦鎬佸絳夊嚑鏂歸潰錛?br />銆€銆€1,鐥呯悊褰㈡€佸鐨勫垎綾夥細灝嗚偤鐐庡垎鎴愬ぇ鍙惰偤鐐?鏀皵綆¤偤鐐?闂磋川鑲虹値鍙婃瘺緇嗘敮姘旂鐐庣瓑.銆€銆€2,鏍規嵁鐥呭師浣撶綾夥細鍖呮嫭緇嗚弻鎬ц偤鐐?甯歌緇嗚弻鏈夎偤鐐庨摼鐞冭弻,钁¤悇鐞冭弻,鍡滆嫻佹劅鏉嗚弻絳? 鐥呮瘨鎬ц偤鐐?甯歌鐥呮瘨濡傚懠鍚擱亾鍚堣優鐥呮瘨,嫻佹劅鐥呮瘨,鍓祦鎰熺棶姣?鑵虹棶姣掔瓑.鍙﹀榪樻湁鐪熻弻鎬ц偤鐐?鏀師浣撹偤鐐?琛ｅ師浣撹偤鐐庣瓑.銆€銆€3,鏍規嵁鐥呯▼鍒嗙被錛氬垎涓烘€ユ€ц偤鐐?,榪佸歡鎬ц偤鐐庡強鎱㈡€ц偤鐐?涓€鑸縼寤舵€ц偤鐐庣棶紼嬮暱杈?鍀?鏈?瓚呰繃3涓湀鍒欎負鎱㈡€ц偤鐐?琛ｅ師浣撹偤鐐庣殑娌葷枟鍘熷墶涓庝竴鑸偤鐐庣殑娌葷枟鍘熷墶澶ц嚧鐩稿悓. 銆€銆€1.涓€鑸不鐤?娉ㄦ剰鍔犲己鎶ょ悊鍜屼紤鎭?淇濇寔瀹ゅ唴絀烘皵鏂伴矞,騫朵繚鎸侀€傚綋瀹ゆ俯鍙婃箍搴?淇濇寔鍛煎惛閬撻€氱晠,緇忓父緲昏韓鏇存崲浣撲綅.鐑﹁簛涓嶅畨鍙姞閲嶇己姘?鏁呭彲緇欓€傞噺鐨勯晣闈欒嵂鐗?渚涚粰鐑噺涓板瘜騫跺惈鏈変赴瀵岀淮鐢熺礌,鏄撲簬娑堝寲鍚告敹鐨勯鐗╁強鍏呰凍姘村垎. 銆€銆€2.鎶楃敓緔犳不鐤?銆€銆€錛?錛夊ぇ鐞冨唴閰被鎶楃敓緔犫憼綰㈤湁緔狅細琛ｅ師浣撹偤鐐庣殑鎶楃敓緔犲簲棣栭€夌孩闇夌礌,鐢ㄩ噺涓?0mg/(kg路d),鍒?鍀?嬈″彛鏈嶈繛鐢?鍛?閲嶇棁鎴栦笉鑳藉彛鏈嶈€?鍙潤鑴夌粰鑽?鐪兼唱涓孩闇夌礌鍙揪鏈夋晥嫻撳害,榪樺彲娓呴櫎榧誨捊閮ㄦ矙鐪艱。鍘熶綋,鍙闃叉矙鐪艱。鍘熶綋鑲虹値鐨勫彂鐢?鈶＄綏綰㈤湁緔犳垨緗楀姏寰楋細鐢ㄩ噺涓?鍀?mg/(kg路d),鍒?嬈′簬鏃╂櫄槨愬墠鏈嶇敤,榪炵敤2鍛?濡傚湪絎?鐤楃▼鍚庝粛鏈夊挸鍡藉拰鐤蹭箯,鍙敤絎?鐤楃▼.鈶㈤樋濂囬湁緔狅紙sumamed錛夛細鏄竴縐嶆愛鐜唴鑴傜被鎶楃敓緔?緇撴瀯涓庡ぇ鐜唴鑴傜被鎶楃敓緔犵溮浼?鍙ｆ湇鍚告敹寰堝ソ,鏈€楂樿娓呮祿搴︿負0.4mg/L.鑳借繀閫熷垎甯冧簬鍚勭粍緇囧拰鍣ㄥ畼.瀵矽。鍘熶綋浣滅敤寮?娌葷枟緇撴潫鍚?鑽墿鍙淮鎸佸湪娌葷枟姘村鉤5鍀?d.t1/2涓?2鍀?4h,姣忔棩鍙ｆ湇1嬈?鐤楃▼鐭?浠ヨ嵂鐗╁師鍨嬬粡鑳嗘眮鎺掓硠.涓庢姉閰歌嵂鐗╃殑緇欒嵂鏃墮棿鑷沖皯闂撮殧2h.灝氭湭鍙戠幇涓庤尪紕辯被,鍙ｆ湇鎶楀嚌琛€鑽?鍗￠┈瑗垮鉤,鑻Ε鑻遍挔,鍦伴珮杈涚瓑鏈夌溮浜掍綔鐢?鍎跨錛堜綋閲?0kg浠ヤ笂錛夌涓€澶╂瘡嬈?0mg/kg,浠ュ悗4d姣忓ぉ姣忔5mg/kg,1嬈￠】鏈?鍏舵姉鑿屼綔鐢ㄨ嚦灝戠淮鎸?0澶?鈶ｇ敳綰㈤湁緔狅紙clarithromycin錛夛細鍦ㄤ綋澶栧鑲虹値琛ｅ師浣撳唴鑴傜被鑽墿娌葷枟鑲虹値琛ｅ師浣撴劅鏌撲笌綰㈤湁緔犲悓鏍鋒湁鏁?鐢熸椿鎶ょ悊錛?br />1,澶氱炕韜媿鑳?甯姪鍛煎惛閬撳垎娉岀墿鎺掑嚭.瀹濆疂鍜沖椊澶氭椂,鐫¤鏃朵細寰堥毦鍙?鐖稿璁板緱澶氱粰瀹濆疂緲昏韓鎷嶈儗,甯姪瀹濆疂鎶婂懠鍚擱亾鐨勫垎娉岀墿鎺掑嚭.銆€銆€2,澶氬悆姘存灉,姹ゆ眮,灝戝悆楦¤泲.椋熺墿瑕佹竻娣?瑕佸琛ュ厖姘村垎鍜岀淮鐢熺礌C,浣嗘敞鎰忎笉瑕佷竴嬈″悆寰楀お澶?錏嬬櫧璐ㄨ繃澶氫細寮曡搗娑堝寲涓嶈壇.銆€銆€3,榧誨浣跨敤緇嗘媯?鍚擱薊鍣?瀹濆疂榧誨,榧誨牭鏃跺彲鐢ㄦ簿鏈夋俯姘寸殑媯夋婀挎鼎榧葷梻,涓€鐐逛竴鐐瑰湴灝嗛薊鐥傚彇鍑?鐖稿娉ㄦ剰鍗冧竾涓嶅彲浠ョ敤鍔涜繃鐚涘摝.閫夋嫨緇嗗皬鐨勬媯?瀹冩瘮浼犵粺鐨勬媯掓洿濂界敤.鍚擱薊鍣ㄥ湪榪欐椂涔熻兘媧句笂鐢ㄥ満.銆€銆€4,鑷娓╂箍搴﹁,淇濇寔絀烘皵嫻侀€?姣忓ぉ寮€紿?鍒?嬈?鑷涓€涓俯婀垮害璁?澶ц秴甯傞噷灝辨湁鍗栫殑鍝?淇濇寔瀹ゅ唴鐨勭┖姘旀祦閫?姣忓ぉ寮€紿?鍒?嬈?鎺у埗瀹ゅ唴鐨勬俯婀垮害,娓╁害綰﹀湪18鈩冿綖22鈩?婀垮害綰﹀湪60錛呭乏鍙?銆€銆€5,鏁烽澶達紙閫€鐑創錛?閰掔簿鎿﹁韓.濡傛灉瀹濆疂鏈夊彂鐑х殑鎯呭喌,鍐鋒瘺宸炬暦棰濆ご鍙互緇欏疂瀹濋檷鐑?鍘葷儹璐翠篃鍙互閫夌敤鍝?鍙﹀,30錛咃綖50錛呯殑閰掔簿鎿﹁韓涔熷彲浠ュ府鍔╁疂瀹濈墿鐞嗛檷娓?